WebApr 11, 2024 · Histological Evaluation of Lung Damage and Collagen Deposition of BLM-Induced Lung Injury To assess the development of PF, mice were assessed at day 7 and 14. For the lung tissue collection, mice were euthanized by CO 2 inhalation. The chest cavity was exposed, and the lungs were perfused and washed with ice-cold PBS. WebFeb 25, 2024 · Effects of SH on Histological Changes in BLM Mice. Histological examinations were performed to investigate the effects of SH on lung morphology in BLM mice. As shown in Figure 3, BLM markedly increased lung inflammatory cell infiltration and edema in H and E stained slides in a time dependent manner (Figure 3 Control and BLM …
Systematic analyses identify the anti-fibrotic role of lncRNA
WebOct 26, 2024 · More recently, a major improvement has been brought in these BLM mouse models by using repetitive administration of low-dose BLM (3 to 8) IT instillations of 0.8 UI/g BLM spaced two weeks apart), based on the IPF pathogenic hypothesis of repetitive alveolar micro-injuries. WebDrug intervention studies in the bleomycin model. The bleomycin animal model is widely used in the assessment of potential antifibrotic agents. A large number of compounds … the pump man teeswater
Pulmonary fibrosis model of mice induced by different …
WebApr 3, 2024 · Mice were administered BLM or saline through osmotic minipumps for seven days, and the development of fibrosis was evaluated on day 21 after the first day of BLM infusion ( Supplementary Figure S1A ). The body weight of the mice was measured daily. WebApr 18, 2024 · We assessed the model of pulmonary fibrosis after 14d and 42d of BLM administration. At the designated endpoint, serum and BALF of mice were collected. Then the mice were sacrificed, and lung tissues … Web[The Blm(-/-) mice: an stage towards the understanding the molecular mechanisms at play in Bloom syndrome] Bull Cancer. 1999 Mar;86(3):249. [Article in French] Author M L … significance of pink rose