NettetSino Biological has developed a panel of high-quality recombinant IL-21 and IL-21 receptor proteins to support the study of this cytokine. Recombinant IL-21 Cytokines and Receptors Sino Biological has developed bioactive recombinant IL-21 cytokines from various species, such as human, mouse, rat, and canine. Nettetfor 1 dag siden · However, because of its short half-life, recombinant IL-12 necessitated frequent dosing, which led to high-amplitude IFNγ responses and ultimately dose-limiting toxicities in the clinic. ... Mutations were introduced to stabilize mouse (m)IgG2a-Fc heterodimers 19, 21 and to abrogate FcγR binding 22, 23 ...
Frontiers The Half-Life-Extended IL21 can Be Combined …
NettetRecombinant Mouse IL-21 Protein Bioactivity Recombinant Mouse IL-21 (Catalog # 594‑ML) enhances IFN-gamma secretion in NK-92 human natural killer lymphoma cells. The ED 50 is 3-30 ng/mL. Recombinant Mouse IL-21 Protein SDS-PAGE 1 μg/lane of Recombinant Mouse IL-21 was resolved with SDS-PAGE under reducing (R) … Nettet1. des. 2024 · The serum half-life of rhIL-21 has been reported to be only about 0.2 h in mice [9], 0.4–0.8 h in cynomolgus monkeys [10], and 2 h in humans [11], [12]. Therefore, it is critical to increase the half-life of IL-21 for sustained exposure in the clinical setting. toh dump hours
Fusion of a Short Peptide that Binds Immunoglobulin G to a Recombinant …
Nettet8. mai 2024 · The IL-21 cytokine has generated considerable interest as a potential … NettetIL-21 stands for interleukin 21. Mouse IL-21 is a recombinant protein optimized for … Nettet21. feb. 2024 · Pharmacokinetic study demonstrated that the combination profoundly prolonged the half-life of IL-15 to 13.1 h in mice, about 18 folds longer than that of IL-15 monomer which is around 0.7 h. toh download among us