WebMar 10, 2024 · Louise Emmett presents on the modulation of prostate-specific membrane antigen (PSMA) expression by androgen deprivation therapy (ADT). The study is comprised of serial PSMA PET in men with either hormone-sensitive or castrate-resistant prostate cancer commencing androgen blockade. WebFeb 19, 2024 · Gynecomastia shows increased PSMA uptake and might be observed in patients undergoing ADT [ 53 ]. Decreased PSMA expression Although most pitfalls represent potential false-positive findings, some factors may induce potential false-negative PSMA findings, as well. Up to 5% of prostate adenocarcinomas do not express PSMA.
Does ADT affect tumour detection with PSMA PET/CT scans?
WebWhile ADT, with or without nonsteroidal antiandrogens, has been the backbone of mHSPC treatment for many decades, ADT alone is no longer considered sufficient treatment for … WebDownload scientific diagram Baseline and post-therapy whole-body bone scan and ⁶⁸Ga-PSMA PET/CT (MIP and axial fused image above) of a man with newly diagnosed Gleason score 4 + 3 PSA 36 ... bygclickdownloadercom
Status of PSMA-targeted radioligand therapy in prostate cancer: …
WebAug 5, 2024 · The study analyzed the influence of long-term ADT on PSMA PET/CT findings. They found that they visualized 31 prostate caner lesions in ten men before they started ADT. During ongoing ADT (duration of 42 to 369 days with a median of 230 days), only 14 lesions were visible in eight of the ten men. WebThere has been one prospective RCT seeking to compare immediate with delayed ADT (TOAD). 63 While this study did not reach its accrual goals, enrolling 261 of a planned 750 patients, there was a borderline significant improvement in OS with early ADT (HR=0.55; 95%CI 0.30 to 1.00; p=0.050). Given the small sample size and inclusion of some ... byg barney season 1